Porcine Urinary Bladder Extracellular Matrix for Treatment of Periocular Skin Defects. (May 2021)

• Record Type: Journal Article
• Authors: Law, James J.; Baker, Laura X.; Chen, Qingxia; Mawn, Louise A.; Barahimi, Behin; Kupcha, Anna C.; Alford, Mark A.; Sobel, Rachel K.
• Is Part Of: Ophthalmic plastic and reconstructive surgery. Volume 37(2021)Supplement 3S
• Publication Date: 2021-05
• Subjects: Eye -- Surgery -- Periodicals; Ophthalmic plastic surgery -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Ophthalmologic Surgical Procedures -- Periodicals; Ophthalmology -- Periodicals; Surgery -- Periodicals; 617.70592
• DOI: 10.1097/IOP.0000000000001738
• Languages: English
• ISSNs: 0740-9303

Abstract

Abstract : Purpose: To describe the experience of 4 oculoplastic surgeons with porcine bladder matrix for periocular anterior lamella and donor site skin defects either as stand-alone treatment or in conjunction with other reconstructive procedures. The authors hypothesized that defect size and location influence the requirement for additional matrix treatments or ancillary procedures. Methods: Following the Institutional Review Board approval, the authors conducted a retrospective review of 17 patients treated with porcine bladder matrix at 2 oculoplastic practices between 2016 and 2018. Powdered matrix was applied to the skin defect and overlaid with a matrix sheet. Subsequent rounds of matrix treatment or other reconstructive procedures were performed as necessary. Defect size and location were correlated to the number of ancillary matrix treatments or surgical procedures via univariate analysis. Results: Twenty-five sites (21 primary and 4 donor) in 17 individuals (8–95 years, M = 58.8 years, 10 males) were treated with porcine bladder matrix. All wounds healed successfully. Additional matrix treatments were administered at 5 sites. Ancillary procedures were performed for 7 sites. Upper lid involvement and larger defect size tended to require additional ancillary procedures ( p = 0.006), while lower eyelid and other periocular defects required fewer procedures ( p < 0.001). Conclusion: Porcine bladder matrices are useful adjuncts to healing periocular anterior lamella defects in various settings. Such repairs are useful in nonsurgical candidates, but must take into account varying levels of complexity based on lesion location. Smaller defects are more conducive to application of matrices as stand-alone treatment, while larger or upper eyelid defects often require additional procedures. Abstract : A retrospective case series of 19 patients whose periocular skin defects were managed with porcine urinary bladder matrices alone, or in combination with ancillary surgery. Lesion size and location influenced requirement for additional surgical treatment.