Lower Risk of Multisystem Inflammatory Syndrome in Children With the Delta and Omicron Variants of Severe Acute Respiratory Syndrome Coronavirus 2. (3rd August 2022)

• Record Type: Journal Article
• Authors: Cohen, Jonathan M; Carter, Michael J; Cheung, C Ronny; Ladhani, Shamez
• Is Part Of: Clinical infectious diseases. Volume 76:Number 3(2023)
• Page Start: e518
• Page End: e521
• Publication Date: 2022-08-03
• Subjects: SARS-CoV-2 -- coronavirus -- COVID-19 -- PIMS-TS -- MIS-C; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac553
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Little is known about the risk of multisystem inflammatory syndrome in children (MIS-C) with different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. In southeast England, MIS-C rates per confirmed SARS-CoV-2 infections in children aged 0–16 years were 56% lower (rate ratio [RR], 0.34 [95% confidence interval {CI}, .23–.50]) during prevaccine Delta, 66% lower (RR, 0.44 [95% CI, .28–.69]) during postvaccine Delta, and 95% lower (RR, 0.05 [95% CI, .02–.10]) during the Omicron period.