Paired electrochemical C–H bromination of (hetero)arenes with 2-bromoethan-1-ol. Issue 4 (13th January 2023)

• Record Type: Journal Article
• Authors: Lv, Yanxia; Hou, Zhong-Wei; Li, Pinhua; Wang, Lei
• Is Part Of: Organic chemistry frontiers. Volume 10:Issue 4(2023)
• Page Start: 990
• Page End: 995
• Publication Date: 2023-01-13
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01425d
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A site-selective electrochemical C–H bromination of (hetero)arenes with 2-bromoethan-1-ol by releasing available ethylene oxide and hydrogen through paired electrolysis has been developed. Abstract : A site-selective electrochemical C–H bromination of (hetero)arenes with 2-bromoethan-1-ol through paired electrolysis has been developed. The C–H bromination reactions depend on the anodic oxidation of Br − produced by the cathodic reduction of 2-bromoethan-1-ol with available ethylene oxide and hydrogen evolution. The method has good compatibility with common functional groups and the scale-up electrolysis can easily be performed. A wide variety of brominated products were obtained with satisfactory yields at room temperature in a simple undivided cell.