Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit. (17th August 2022)

• Record Type: Journal Article
• Authors: Smoke, Steven M; Brophy, Alison; Reveron, Samuel; Iovleva, Alina; Kline, Ellen G; Marano, Michael; Miller, Lincoln P; Shields, Ryan K
• Is Part Of: Clinical infectious diseases. Volume 76:Number 3(2023)
• Page Start: e1261
• Page End: e1265
• Publication Date: 2022-08-17
• Subjects: cefiderocol -- carbapenem-resistant Acinetobacter baumannii -- burn -- antibiotic resistance -- whole-genome sequencing; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac647
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii . Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.