Continued Increase of Erythromycin Nonsusceptibility and Clindamycin Nonsusceptibility Among Invasive Group A Streptococci Driven by Genomic Clusters, United States, 2018–2019. (10th June 2022)

• Record Type: Journal Article
• Authors: Li, Yuan; Rivers, Joy; Mathis, Saundra; Li, Zhongya; McGee, Lesley; Chochua, Sopio; Metcalf, Benjamin J; Fleming-Dutra, Katherine E; Nanduri, Srinivas A; Beall, Bernard
• Is Part Of: Clinical infectious diseases. Volume 76:Number 3(2023)
• Page Start: e1266
• Page End: e1269
• Publication Date: 2022-06-10
• Subjects: group A Streptococcus -- invasive disease -- antimicrobial resistance -- genomic cluster; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac468
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We analyzed 9630 invasive GAS surveillance isolates in the USA. From 2015–2017 to 2018–2019, significant increases in erythromycin-nonsusceptibility (18% vs 25%) and clindamycin-nonsusceptibility (17% vs 24%) occurred, driven by rapid expansions of genomic subclones. Prevention and control of clustered infections appear key to containing antimicrobial resistance.