Smart nanoengineered electronic-scaffolds based on triboelectric nanogenerators as tissue batteries for integrated cartilage therapy. (March 2023)

• Record Type: Journal Article
• Authors: Yue, Ouyang; Wang, Xuechuan; Hou, Mengdi; Zheng, Manhui; Hao, Dongyu; Bai, Zhongxue; Zou, Xiaoliang; Cui, Boqiang; Liu, Chunlin; Liu, Xinhua
• Is Part Of: Nano energy. Volume 107(2023)
• Publication Date: 2023-03
• Subjects: Articular cartilage -- Tissue battery -- Triboelectric nanogenerator -- Cartilage repair -- In-situ black-box detection; Nanoscience -- Periodicals; Nanotechnology -- Periodicals; Nanostructured materials -- Periodicals; Power resources -- Technological innovations -- Periodicals; Nanoscience; Nanostructured materials; Nanotechnology; Power resources -- Technological innovations; Periodicals; 621.042
• DOI: 10.1016/j.nanoen.2022.108158
• Languages: English
• ISSNs: 2211-2855

Abstract

Abstract: At present, cartilage defect therapy requires a long-term repair period and does not permit real-time detection of the cartilage repair state named "black box". Inspired by the electroactive nature of living organisms, next-generation tissue trauma therapy with integrated bioelectronics promises to achieve the desired therapeutic effects. Here, a tissue battery for integrated cartilage therapy was nanoengineered through the on-demand integration of intelligent scaffolds with a porous three-dimensional structure and multi-convex triboelectric nanogenerator (TENG)-based sensor. The proposed cartilage tissue battery is repair-induced, self-powered, highly sensitive, implantable, intelligently degradable, and anti-interference. The sensor based on the contact separation TENG mechanism has a high sensitivity (52.5 V MPa –1 ) within the pressure range of joint movement (0–1.8 MPa), enabling the tissue battery to in-situ detect the real-time status of cartilage repair in the "black box". Additionally, in vitro and in vivo experiments demonstrated that the tissue battery converts mechanical energy into electricity to stimulate chondrocyte proliferation in the scaffold, thereby shortening the cartilage repair period. The proposed tissue battery for tissue repair under electrical stimulation is beneficial for reducing pain and treatment costs for patients with cartilage defects and is a promising strategy for bioelectronic implants. Graphical Abstract: ga1 Highlights: A tissue-battery for cartilage therapy was nanoengineered through integration of intelligent scaffold and TENG-based sensor. The tissue battery exhibited self-powered, highly sensitive, implantable, intelligently degradable, and anti-interference. The tissue battery realized in-situ real-time detection of cartilage repair in the "black box". The tissue-battery generate electricity to stimulate chondrocyte proliferation, thereby promoting the cartilage repair.