Rewiring of metabolic pathways in yeasts for sustainable production of biofuels. (March 2023)

• Record Type: Journal Article
• Authors: Maurya, Rupesh; Gohil, Nisarg; Nixon, Snovia; Kumar, Nilesh; Noronha, Santosh B.; Dhali, Debarun; Trabelsi, Heykel; Alzahrani, Khalid J.; Reshamwala, Shamlan M.S.; Awasthi, Mukesh Kumar; Ramakrishna, Suresh; Singh, Vijai
• Is Part Of: Bioresource technology. Volume 372(2023)
• Publication Date: 2023-03
• Subjects: Biofuels -- Microbial cell factories -- Metabolic engineering -- Yeast -- Fatty acids; Biomass -- Periodicals; Biomass energy -- Periodicals; Bioremediation -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Bioénergie -- Périodiques; Déchets agricoles -- Périodiques; Déchets industriels -- Périodiques; Déchets organiques -- Périodiques; Déchets (Combustible) -- Périodiques; 662.88
• DOI: 10.1016/j.biortech.2023.128668
• Languages: English
• ISSNs: 0960-8524

Abstract

Graphical abstract: Highlights: Recent advances in biofuel production using engineered yeasts cells Engineering approaches used for enhanced biofuels production in yeast cell factories Strategies for production of advanced biofuels using engineered yeasts Non-conventional yeasts as cell factories for biofuel production Abstract: The ever-increasing global energy demand has led world towards negative repercussions such as depletion of fossil fuels, pollution, global warming and climate change. Designing microbial cell factories for the sustainable production of biofuels is therefore an active area of research. Different yeast cells have been successfully engineered using synthetic biology and metabolic engineering approaches for the production of various biofuels. In the present article, recent advancements in genetic engineering strategies for production of bioalcohols, isoprenoid-based biofuels and biodiesels in different yeast chassis designs are reviewed, along with challenges that must be overcome for efficient and high titre production of biofuels.