A dual-mode probe based on AIE and TICT effects for the detection of the hypochlorite anion and its bioimaging in living cells. Issue 6 (13th January 2023)

• Record Type: Journal Article
• Authors: Zhou, Yang; Xu, Hai; Li, Qing-Xiu; Hou, Zong-Rui; Wang, Ya-Wen; Peng, Yu
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 6(2023)
• Page Start: 1270
• Page End: 1274
• Publication Date: 2023-01-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob02138b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel AIE-based fluorescent probe has been developed for the detection of the hypochlorite anion in a higher water phase. Abstract : Based on aggregation-induced emission (AIE) and twisted intramolecular charge transfer (TICT) mechanisms, a fluorescent probe SWJT-12 for the detection of ClO − was designed by using the CN bond as a reactive group. This synthesized probe can react with ClO − in a high aqueous phase, and it shows a large Stokes shift (144 nm) and low biological toxicity. Its limit of detection was calculated to be 0.28 μM. Furthermore, SWJT-12 was successfully used for ratiometric imaging of the exogenous hypochlorite anion in living cells.