Metabolic dialogs between B cells and the tumor microenvironment: Implications for anticancer immunity. (1st March 2023)

• Record Type: Journal Article
• Authors: Jiang, Su; Feng, Ranran; Tian, Ziying; Zhou, Jieyu; Zhang, Wenling
• Is Part Of: Cancer letters. Volume 556(2023)
• Publication Date: 2023-03-01
• Subjects: B-Cell differentiation -- Immunometabolism -- Anticancer immunity -- Glycolysis -- B-Cell-derived metabolites; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2023.216076
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Immunometabolism, a branch of biology describing the link between immunity and metabolism, is an emerging topic in cancer immunology. It is currently well accepted that B cells and tertiary lymph structures formed by them are associated with favorable outcomes when patients undergo cancer immunotherapy. Understanding the determinants of B-cell fate and function in cancer patients is necessary for improving cancer immunotherapy. Accumulating evidence points to the tumor microenvironment being a critical metabolic hurdle to an efficient antitumor B-cell response. At the same time, several B-cell-derived metabolites have recently been reported to inhibit anticancer immunity. In this literature review, key B-cell immunometabolism studies and the metabolic life of B cells were summarized. Then, we discussed the intrinsic metabolic pathways of B cells themselves and how the tumor microenvironment and B cells in tumors metabolically influence each other. Finally, we pointed out key questions to provide some inspiration for further study of the role of B-cell immunometabolism in the antitumor immune response. Graphical abstract: Image 1 Highlights: Metabolites made by B cells can dampen antitumor immunity. Metabolites in the tumor microenvironment can influence anticancer B-cell immunity. Oxygen and nutrient competition between cancer cells and B cells might impair anticancer immunity.