Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children. (23rd January 2023)

• Record Type: Journal Article
• Authors: Hijano, Diego R; Ferrolino, Jose A; Hidinger, Jennifer; Brazelton, Jessica N; Gu, Zhengming; Suganda, Sri; Glasgow, Heather L; Allison, Kim J; Peterson, Megan; Dallas, Ronald H; Maron, Gabriela; Hayden, Randall T
• Is Part Of: Open forum infectious diseases. Volume 10:Number 2(2023)
• Publication Date: 2023-01-23
• Subjects: adenovirus -- children -- digital PCR -- immunocompromised -- viral load; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofad030
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.