One‐Pot Controllable Assembly of a Baicalin‐Condensed Aptamer Nanodrug for Synergistic Anti‐Obesity (Small 6/2023). Issue 6 (8th February 2023)

• Record Type: Journal Article
• Authors: Tian, Jingjing; He, Xiaoyun; Lan, Xinyue; Liang, Xingxing; Zhong, Zhaobin; Zhu, Longjiao; Chen, Keren; Chang, Qiaoying; Xu, Wentao
• Is Part Of: Small. Volume 19:Issue 6(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-08
• Subjects: aptamers -- baicalin -- controllable assembly -- nanodrugs -- obesity therapies; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202370033
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Baicalin‐Condensed Aptamer Nanodrugs Polymerase chain reaction (PCR)‐driven DNA micro‐nano‐flowers are used to construct a nanosized baicalin‐compressed‐aptamer‐nanodrug (bcaND) via one‐pot assembly. The tailored Adipo‐8 (tAdi‐8) overhang in the PCR amplicon, like an arrow, displays anti‐obesity targeting activity, while the baicalin loaded in the bcaND plays a three‐fold role as a lipid‐lowering factor, bcaND size compressor, and uncoupling protein‐1 (UCP1)‐raised thermogenic activator. More details can be found in article number 2205933 by Wentao Xu and co‐workers.