Chiral Transport in Nanochannel Based Artificial Drug Transporters. Issue 6 (4th December 2022)

• Record Type: Journal Article
• Authors: Yang, Lei; Sun, Zhongyue; Zhang, Siyun; Sun, Yue; Li, Haibing
• Is Part Of: Small. Volume 19:Issue 6(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-04
• Subjects: biomimetic nanochannels -- chirality -- drug transport -- gate effect -- propranolol; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202205274
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: The precise regulation of chiral drug transmembrane transport can be achieved through drug transporters in living organisms. However, implementing this process in vitro is still a formidable challenge due to the complexity of the biological systems that control drug enantiomeric transport. Herein, a facile and feasible strategy is employed to construct chiral L ‐tyrosine‐modified nanochannels ( L ‐Tyr nanochannels) based on polyethylene terephthalate film, which could enhance the chiral recognition of propranolol isomers ( R ‐/ S ‐PPL) for transmembrane transport. Moreover, conventional fluorescence spectroscopy, patch‐clamp technology, laser scanning confocal microscopy, and picoammeter technology are employed to evaluate the performance of nanochannels. The results show that the L ‐Tyr nanochannel have better chiral selectivity for R ‐/ S ‐PPL compared with the L ‐tryptophan ( L ‐Trp) channel, and the chiral selectivity coefficient is improved by about 4.21‐fold. Finally, a detailed theoretical analysis of the chirality selectivity mechanism is carried out. The findings would not only enrich the basic theory research related to chiral drug transmembrane transport, but also provide a new idea for constructing artificial channels to separate chiral drugs. Abstract : Herein, the L‐ amino acids are introduced through biomimetic strategy to fabricate the gated nanochannels for the chiral drugs. The gated transport effect of l ‐tyrosine nanochannels on propranolol enantiomers is found, which is not presented by other nanochannels. The research would provide a new idea for constructing artificial channels to regulate chiral drug delivery.