Molecular and regulatory mechanisms of oxidative stress adaptation in Streptococcus mutans. (25th September 2022)

• Record Type: Journal Article
• Authors: Yu, Shuxing; Ma, Qizhao; Li, Yuqing; Zou, Jing
• Is Part Of: Molecular oral microbiology. Volume 38:Number 1(2023)
• Page Start: 1
• Page End: 8
• Publication Date: 2022-09-25
• Subjects: oxidative stress adaptation -- protective molecules -- regulatory mechanisms -- Streptococcus mutans; Mouth -- Microbiology -- Periodicals; Respiratory infections -- Microbiology -- Periodicals; Mouth -- Diseases -- Immunological aspects -- Periodicals; 617.522
• DOI: 10.1111/omi.12388
• Languages: English
• ISSNs: 2041-1006

Abstract

Abstract: Dental caries is a chronic progressive disease, which destructs dental hard tissues under the influence of multiple factors, mainly bacteria. Streptococcus mutans is the main cariogenic bacteria. However, its cariogenic virulence is affected by environmental stress such as oxidative stress, nutrient deficiency, and low pH to some extent. Oxidative stress is one of the main stresses that S. mutans faces in oral cavity. But there are a variety of protective molecules to resist oxidative stress in S. mutans, including superoxide dismutase, nicotinamide adenine dinucleotide oxidase, Dps‐like peroxide resistance protein, alkyl‐hydrogen peroxide reductase, thioredoxin, glutamate‐reducing protein system, and some metabolic substances. Additionally, some transcriptional regulatory factors (SloR, PerR, Rex, Spx, etc.) and two‐component systems are also closely related to oxidative stress adaptation by modulating the expression of protective molecules. This review summarizes the research progress of protective molecules and regulatory mechanisms (mainly transcription factors) of oxidative stress adaptation of S. mutans .