A helical oncolytic polypeptide with potent membranolytic activity for cancer therapy. (5th January 2023) - Hu, Xue
Abstract : A series of easy-to-synthesize, helical oncolytic polypeptides (OLPP n ) with enzyme resistance and potent membranolytic activity were synthesized for cancer therapy. Abstract : Oncolytic peptides (OLPs) with membranolytic activity show great potential to combat multidrug-resistant cancer cells. Herein, we report a cationic helical oncolytic polypeptide (OLPP) with potent membranolytic activity for cancer therapy. The OLPP was synthesized by ring-opening polymerization of N -carboxyanhydrides (NCAs) and thiol–ene reaction. The OLPP was resistant to protease, showed high cytotoxicity to a series of cancer cells and caused cancer cell necrosis by quickly lysing cancer cell membrane independent of classic death-related intracellular pathways. Intra-tumoral injection of the OLPP effectively suppressed tumor growth in mice through the direct oncolytic effect. The OLPP represents a potential oncolytic chemotherapeutics for cancer therapy.