Clinical Trials of Broadly Neutralizing Monoclonal Antibodies for Human Immunodeficiency Virus Prevention: A Review. (1st July 2020)

• Record Type: Journal Article
• Authors: Mahomed, Sharana; Garrett, Nigel; Baxter, Cheryl; Abdool Karim, Quarraisha; Abdool Karim, Salim S
• Is Part Of: Journal of infectious diseases. Volume 223:Number 3(2021)
• Page Start: 370
• Page End: 380
• Publication Date: 2020-07-01
• Subjects: monoclonal antibodies -- broadly neutralizing antibodies -- HIV -- clinical trials; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa377
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Passive immunization with broadly neutralizing antibodies (bnAbs) is a promising approach to reduce the 1.7 million annual human immunodeficiency virus (HIV) infections globally. Early studies on bnAbs showed safety in humans, but short elimination half-lives and low potency and breadth. Since 2010, several new highly potent bnAbs have been assessed in clinical trials alone or in combination for HIV prevention. Published data indicate that these bnAbs are safe and have a half-life ranging from 15 to 71 days. Only intravenous VRC01 has advanced to an efficacy trial, with results expected in late 2020. If bnAbs are shown to be effective in preventing HIV infection, they could fast-track vaccine development as correlates of protection, and contribute as passive immunization to achieving the goal of epidemic control. The purpose of the current review is to describe the current status and provide a synopsis of the available data on bnAbs in clinical trials for HIV prevention. Abstract : The use of broadly neutralizing antibodies (bnAbs) is a promising approach that could help reduce the human immunodeficiency virus (HIV) epidemic burden. This review describes the status and available data on bnAbs in clinical trials for HIV prevention.