Electrochemical oxidative cascade cyclization of olefinic amides and alcohols leading to the synthesis of alkoxylated 4H-3, 1-benzoxazines and indolines. Issue 3 (19th January 2023) - Wei, Wan-Jie
Abstract : We have developed a mild and efficient electrochemical oxidative strategy to construct anticancer alkoxylated 4 H -3, 1-benzoxazines and indolines without the requirement for a transition-metal catalyst and an external oxidant. Abstract : Synthesis technologies can be used directly and selectively to construct two different heterocycles from one substrate. Herein, we introduce a mild and efficient electrochemical oxidative strategy to construct alkoxylated 4 H -3, 1-benzoxazines and indolines. High atom efficiency and transition metal- and oxidant-free conditions are the striking features of this protocol. In a simple undivided cell, various olefinic amides and alcohols react to generate 40 examples of benzoxazines and indolines. This radical cascade reaction provides a facile method for constructing C–O bonds in one step. Furthermore, most of the compounds exhibit good inhibitory activity on tumour cell lines.