Easy access to α-carbonyl sulfones using cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides. Issue 5 (9th January 2023)

• Record Type: Journal Article
• Authors: Sharma, Anup Kumar; Chand, Shiv; Kumar Pandey, Anand; Singh, Krishna Nand
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 5(2023)
• Page Start: 987
• Page End: 993
• Publication Date: 2023-01-09
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob02219b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Cu-catalyzed cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides is explored to access α-carbonyl sulfones via migratory insertion of Cu-carbene species. Abstract : A facile synthesis of α-carbonyl sulfones has been accomplished by the cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides in the presence of CuI and DBU. The reaction employs inexpensive and bench stable sulfonyl hydrazides as a sulfonyl source, and facilitates the migratory insertion with α-aryl-α-diazoesters under mild reaction conditions.