Immunogenicity of cell death driven by immune effectors. Issue 1 (5th April 2020)

• Record Type: Journal Article
• Authors: Galluzzi, Lorenzo; Petroni, Giulia; Kroemer, Guido
• Is Part Of: Journal for immunotherapy of cancer. Volume 8:Issue 1(2020)
• Publication Date: 2020-04-05
• Subjects: cytotoxicity, immunologic -- CD8-Positive T-Lymphocytes -- receptors, chimeric antigen -- natural killer T-cells; Cancer -- Immunotherapy -- Periodicals; Cancer -- Immunological aspects -- Periodicals; Tumors -- Immunological aspects -- Periodicals; Immunotherapy -- Periodicals; 616.99406105
• DOI: 10.1136/jitc-2020-000802
• Languages: English
• ISSNs: 2051-1426

Abstract

Abstract : Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell–mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.