A polyphenol-rich cranberry extract protects against endogenous exposure to persistent organic pollutants during weight loss in mice. (December 2020)

• Record Type: Journal Article
• Authors: Choi, Béatrice So-Yun; Varin, Thibault Vincent; St-Pierre, Philippe; Pilon, Geneviève; Tremblay, Angelo; Marette, André
• Is Part Of: Food and chemical toxicology. Volume 146(2020)
• Publication Date: 2020-12
• Subjects: Detoxication -- Obesity -- Xenobiotic -- Gut microbiota -- Prebiotic; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2020.111832
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: The dramatic rise in the global occurrence of obesity and associated diseases calls for new strategies to promote weight loss. However, while the beneficial effects of weight loss are well known, rapid loss of fat mass can also lead to the endogenous release of liposoluble molecules with potential harmful effects, such as persistent organic pollutants (POP). The aim of this study was to evaluate the impact of a polyphenol-rich cranberry extract (CE) on POP release and their potential deleterious effects during weight loss of obese mice. C57BL/6 J mice were fed an obesogenic diet with or without a mixture of POP for 12 weeks and then changed to a low-fat diet to induce weight loss and endogenous POP release. The POP-exposed mice were then separated in two groups during weight loss, receiving either CE or the vehicle. Unexpectedly, despite the higher fat loss in the CE-treated group, the circulating levels of POP were not enhanced in these mice. Moreover, glucose homeostasis was further improved during CE-induced weight loss, as revealed by lower fasting glycemia and improved glucose tolerance as compared to vehicle-treated mice. Interestingly, the CE extract also induced changes in the gut microbiota after weight loss in POP-exposed mice, including blooming of Parvibacter, a member of the Coriobacteriaceae family which has been predicted to play a role in xenobiotic metabolism. Our data thus suggests that the gut microbiota can be targeted by polyphenol-rich extracts to protect from increased POP exposure and their detrimental metabolic effects during rapid weight loss. Highlights: Persistent organic pollutants (POP) did not potentiate the effects of HFD on metabolic health and obesity. A polyphenol-rich cranberry extract ameliorated metabolic health during weight loss in a POP contaminated context. Increased loss of adipose tissue upon supplementation with cranberry polyphenols did not increase circulating POP levels. Gut microbiota could play a key role in body detoxication of POP.