Full range of population Eliciting Dose values for 14 priority allergenic foods and recommendations for use in risk characterization. (December 2020)

• Record Type: Journal Article
• Authors: Houben, Geert F.; Baumert, Joseph L.; Blom, W. Marty; Kruizinga, Astrid G.; Meima, Marie Y.; Remington, Benjamin C.; Wheeler, Matthew W.; Westerhout, Joost; Taylor, Steve L.
• Is Part Of: Food and chemical toxicology. Volume 146(2020)
• Publication Date: 2020-12
• Subjects: Food allergy -- Food allergen -- Allergenic food -- Eliciting dose -- Risk assessment -- Risk management; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2020.111831
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Previously, we published selected Eliciting Dose (ED) values (i.e. ED01 and ED05 values) for 14 allergenic foods, predicted to elicit objective allergic symptoms in 1% and 5%, respectively, of the allergic population (Remington et al., 2020). These ED01 and ED05 values were specifically presented and discussed in the context of establishing Reference Doses for allergen management and the calculation of Action Levels for Precautionary Allergen Labeling (PAL). In the current paper, we publish the full range of ED values for these allergenic foods and provide recommendations for their use, specifically in the context of characterizing risks of concentrations of (unintended) allergenic proteins in food products. The data provided in this publication give risk assessors access to full population ED distribution information for 14 priority allergenic foods, based on the largest threshold database worldwide. The ED distributions were established using broad international consensus regarding suitable datapoints and methods for establishing individual patient's NOAELs and LOAELs and state of the art statistical modelling. Access to these ED data enables risk assessors to use this information for state-of-the-art food allergen risk assessment. This paper contributes to a harmonization of food allergen risk assessment and risk management and PAL practices. Highlights: This paper gives the full range Eliciting Dose values for 14 allergenic foods This information can be used for the characterization of risks of allergen exposure The values are to be used in combination with allergenic protein intake information Recommendations are given for the correct use of the values The reliability and safety of the use of the datasets and values are discussed