The Impact of Severe Acute Respiratory Syndrome Coronavirus Type 2 on Children With Liver Diseases: A Joint European Society for Pediatric Gastroenterology, Hepatology and Nutrition and Society of Pediatric Liver Transplantation Position Paper. Issue 1 (21st October 2021)

• Record Type: Journal Article
• Authors: Nicastro, Emanuele; Ebel, Noelle H.; Kehar, Mohit; Czubkowski, Piotr; Ng, Vicky L.; Michaels, Marian G.; Lobritto, Steven J.; Martinez, Mercedes; Indolfi, Giuseppe
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 74:Issue 1(2022)
• Page Start: 159
• Page End: 170
• Publication Date: 2021-10-21
• Subjects: autoimmune hepatitis -- autoimmune liver disease -- coronavirus disease 2019 -- COVID-19 -- immunosuppression -- liver transplantation -- multisystem inflammatory syndrome in children -- MIS-C -- PIMS-TS -- severe acute respiratory syndrome coronavirus type 2 -- SARS-CoV2; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000003339
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : ABSTRACT: Children are seldom affected by severe forms of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV2) infection; however, the impact of comorbidities in the clinical presentation and outcome of SARS-CoV2 in children is poorly characterized including that of chronic liver disease (CLD) and those taking immunosuppressive medications for autoimmune liver disease or following liver transplantation (LT). Although not the main target organ, a spectrum of liver involvement has been described in children infected with SARS-CoV2 and those presenting with Multisystem Inflammatory Syndrome in Children (MIS-C). The Hepatology Committee of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the Society of Pediatric Liver Transplantation (SPLIT) present an evidence-based position paper on liver involvement in children with SARS-CoV2 infection and its impact on those with CLD as well as LT recipients. All children may exhibit acute liver injury from SARS-CoV2 infection, and those with CLD and may experience hepatic decompensation. Preventative and therapeutic measures are discussed.