MTORC1 signaling in hepatic lipid metabolism. Issue 2 (22nd April 2017)

• Record Type: Journal Article
• Authors: Han, Jinbo; Wang, Yiguo
• Is Part Of: Protein & cell. Volume 9:Issue 2(2018)
• Page Start: 145
• Page End: 151
• Publication Date: 2017-04-22
• Subjects: mTOR -- mTORC1 -- lipogenesis -- lipophagy; Proteins -- Periodicals; Cells -- Periodicals; Cytology -- Periodicals; 572.6
• DOI: 10.1007/s13238-017-0409-3
• Languages: English
• ISSNs: 1674-800X

Abstract

Abstract: The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.