Guided digital health intervention for depression in Lebanon: randomised trial. Issue Volume 25:Issue e1(2022) (16th May 2022)

• Record Type: Journal Article
• Authors: Cuijpers, Pim; Heim, Eva; Ramia, Jinane Abi; Burchert, Sebastian; Carswell, Kenneth; Cornelisz, Ilja; Knaevelsrud, Christine; Noun, Philip; van Klaveren, Chris; van't Hof, Edith; Zoghbi, Edwina; van Ommeren, Mark; El Chammay, Rabih
• Is Part Of: Evidence-based mental health. Volume 25:Issue e1(2022)
• Page Start: e34
• Page End: e40
• Publication Date: 2022-05-16
• Subjects: Depression & mood disorders; Psychotherapy -- Periodicals; Psychiatry -- Periodicals; Mental health -- Periodicals; 616.891
• DOI: 10.1136/ebmental-2021-300416
• Languages: English
• ISSNs: 1362-0347

Abstract

Abstract : Background: Most people with mental disorders in communities exposed to adversity in low-income and middle-income countries (LMICs) do not receive effective care. Digital mental health interventions are scalable when digital access is adequate, and can be safely delivered during the COVID-19 pandemic. Objective: To examine the effects of a new WHO-guided digital mental health intervention, Step-by-Step, supported by a non-specialist helper in Lebanon, in the context of concurring economic, humanitarian and political crises, a large industrial disaster and the COVID-19 pandemic. Methods: We conducted a single-blind, two-arm pragmatic randomised trial, comparing guided Step-by-Step with enhanced care as usual (ECAU) among people suffering from depression and impaired functioning. Primary outcomes were depression (Patient Health Questionnaire 9 (PHQ-9)) and impaired functioning (WHO Disability Assessment Schedule-12 (WHODAS)) at post-treatment. Findings: 680 people with depression (PHQ-9>10) and impaired functioning (WHODAS>16) were randomised to Step-by-Step or ECAU. Intention-to-treat analyses showed effects on depression (standardised mean differences, SMD: 0.71; 95% CI: 0.45 to 0.97), impaired functioning (SMD: 0.43; 95% CI: 0.21 to 0.65), post-traumatic stress (SMD: 0.53; 95% CI: 0.27 to 0.79), anxiety (SMD: 0.74; 95% CI: 0.49 to 0.99), subjective well-being (SMD: 0.37; 95% CI: 0.12 to 0.62) and self-identified personal problems (SMD: 0.56; 95% CI 0.29 to 0.83). Significant effects on all outcomes were retained at 3-month follow-up. Conclusions: Guided digital mental health interventions can be effective in the treatment of depression in communities exposed to adversities in LMICs, although some uncertainty remains because of high attrition. Clinical implications: Guided digital mental health interventions should be considered for implementation in LMICs. Trial registration number: ClinicalTrials.gov NCT03720769 .