Electrochemical monofluoroalkylation cyclization of N-arylacrylamides to construct monofluorinated 2-oxindoles. Issue 5 (5th January 2023)

• Record Type: Journal Article
• Authors: Lv, Yanxia; Hou, Zhong-Wei; Wang, Yi; Li, Pinhua; Wang, Lei
• Is Part Of: Organic & biomolecular chemistry. Volume 21:Issue 5(2023)
• Page Start: 1014
• Page End: 1020
• Publication Date: 2023-01-05
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01883g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An electrochemical monofluoroalkylation cyclization of N -arylacrylamides to synthesize monofluorinated 2-oxindoles has been developed. Abstract : An electrochemical monofluoroalkylation cyclization of N -arylacrylamides to synthesize monofluorinated 2-oxindoles has been developed, which employs common dimethyl 2-fluoromalonate as a monofluoroalkyl radical precursor and obviates the use of prefunctionalized monofluoroalkylation reagents and sacrificial oxidants. A variety of monofluorinated nitrogen-containing heterocyclic compounds were efficiently obtained with satisfactory yields from readily available materials.