Mild small-for-gestational-age as a non-negligible risk factor for short stature. (January 2023)

• Record Type: Journal Article
• Authors: Higuchi, Ryunosuke; Koga, Hiroshi; Sugino, Noriko; Bonno, Motoki
• Is Part Of: Early human development. Volume 176(2023)
• Publication Date: 2023-01
• Subjects: Birth cohort -- Fetal growth retardation -- Growth disorders -- Health correlates -- Observational study; GH growth hormone -- NHO National Hospital Organization -- NICU neonatal intensive care unit -- SGA small-for-gestational-age -- SD standard deviation; Fetus -- Periodicals; Neonatology -- Periodicals; Prenatal influences -- Periodicals; 612.65
• DOI: 10.1016/j.earlhumdev.2022.105704
• Languages: English
• ISSNs: 0378-3782

Abstract

Abstract: Risk of subsequent short stature remains unclear among mild small-for-gestational-age (SGA) infants with birthweight <10th percentile and ≥−2 standard deviations. In this multicenter cohort study in Japan, height was found to be <−2 standard deviations at 3 years old even in 18 % of mild-SGA infants. Highlights: Mild small-for-gestational-age (SGA) infants are commonly not indicated for growth hormone therapy. The incidence of short stature or non-catch-up growth has not been well studied in this population. Even among mild-SGA infants, short stature at 3 years of age was observed in 18 %. Our findings provide basic data on the development of mild-SGA infants and risk factors for subsequent short stature.