Behavioral problems in infants and young children with spinal muscular atrophy and their siblings: A cross-sectional study. (January 2023)

• Record Type: Journal Article
• Authors: Panda, Prateek Kumar; Ramachandran, Aparna; Verma, Prashant Kumar; Sharawat, Indar Kumar
• Is Part Of: European journal of paediatric neurology. Volume 42(2023)
• Page Start: 47
• Page End: 52
• Publication Date: 2023-01
• Subjects: Spinal muscular atrophy -- Neuromuscular disorders -- Anxiety -- Depression -- Behavioral problems; Pediatric neurology -- Periodicals; Nervous System Diseases -- Periodicals; Child -- Periodicals; Infant -- Periodicals; Neurologie pédiatrique -- Périodiques; Pediatric neurology; Electronic journals; Periodicals; Electronic journals; 618.928
• DOI: 10.1016/j.ejpn.2022.12.006
• Languages: English
• ISSNs: 1090-3798

Abstract

Abstract: Introduction: Older children and adults with spinal muscular atrophy (SMA) have been shown to have more anxiety, depression, and other behavioral problems in a few studies. But no similar studies have been performed in infants and young children with SMA. Method: Behavioral co-morbidities of young children with SMA were compared with healthy and children with chronic non-neurological illness control group. Infant Behavior Questionnaire-Revised (IBQ-R) and parent-report version of chid behavior checklist (CBCL) were used for infants and preschool-age children respectively. Results: A total of 35 SMA children (age at symptom onset-5.9 ± 2.8 months, at enrolment-21.4 ± 7.1 months, 65% boys, 11, 19 and 5 were SMA 1, 2 and 3 respectively) and 24 siblings (38.6 ± 11.2 months, 71% boys) were enrolled. We also enrolled 15 children with nephrotic syndrome as age and gender matched control to SMA children in age-group 2–5 years (27.7 ± 9.1 months, 67% boys). In infants with SMA, the scale scores of IBQ-R were significantly higher for distress to limitation, fear, sadness, and falling reactivity/rate of recovery from distress (p = 0.005; 0.03; 0.001, and 0.04) and lower for soothability as compared to healthy control group (p = 0.04). Similarly, for the three dimensions of temperament computed from these 13 domains, the mean scale score for surgency/extraversion was lower and negative affectivity was higher (p = 0.04 and 0.03), in infants with SMA as compared to healthy controls. For preschool age group, the internalizing problem scores (p = 0.009 and 0.03) and stress problem scores (p = 0.002 and 0.04) were higher in the SMA group, as compared to both the healthy control group and diseased control group. While assessing the syndrome scale scores, the score was higher for emotionally reactive (p = 0.0002 and 0.01) and anxious domains (p < 0.0001 and p = 0.0002) compared to both healthy and diseased control groups. Conclusion: Infants and young children with SMA suffer from increased internalizing problems like anxiety, depression and probably their healthy siblings are also at increased levels of stress, depicted by increased somatic complaints. Highlights: Behavioral co-morbidities of children with SMA were compared with healthy and children with chronic non-neurological illness. In infants with SMA, the scale scores of IBQ-R were significantly higher for distress, fear, sadness, and falling reactivity. For preschool age group, the internalizing problem scores and stress problem scores were higher in the SMA group. Syndrome scale scores was higher in SMA children for emotionally reactive and anxious domains compared to control groups.