On‐Off Phagocytosis and Switchable Macrophage Activation Stimulated with NIR for Infected Percutaneous Tissue Repair of Polypyrrole‐Coated Sulfonated PEEK. Issue 5 (14th December 2022)

• Record Type: Journal Article
• Authors: Liu, Xingdan; Zhang, Haifeng; Yan, Bangcheng; Yeung, Kelvin W. K.; Liao, Yun; Ouyang, Liping; Liu, Xuanyong
• Is Part Of: Advanced science. Volume 10:Issue 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-14
• Subjects: complement -- macrophage activation -- on‐off phagocytosis -- polyether ether ketone; Science -- Periodicals; 505
• DOI: 10.1002/advs.202205048
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Intelligent control of the immune response is essential for obtaining percutaneous implants with good sterilization and tissue repair abilities. In this study, polypyrrole (Ppy) nanoparticles enveloping a 3D frame of sulfonated polyether ether ketone (SP) surface are constructed, which enhance the surface modulus and hardness of the sulfonated layer by forming a cooperative structure of simulated reinforced concrete and exhibit a superior photothermal effect. Ppy‐coated SP could quickly accumulate heat on the surface by responding to 808 nm near‐infrared (NIR) light, thereby killing bacteria, and destroying biofilms. Under NIR stimulation, the phagocytosis and M1 activation of macrophages cultured on Ppy‐coated SP are enhanced by activating complement 3 and its receptor, CD11b. Phagocytosis and M1 activation are impaired along with abolishment of NIR stimulation in the Ppy‐coated SP group, which is favorable for tissue repair. Ppy‐coated SP promotes Collagen‐I, vascular endothelial growth factor, connective tissue growth factor, and α ‐actin (Acta2) expression by inducing M2 polarization owing to its higher surface modulus. Overall, Ppy‐coated SP with enhanced mechanical properties could be a good candidate for clinical percutaneous implants through on‐off phagocytosis and switchable macrophage activation stimulated with NIR. Abstract : Polypyrrole (Ppy) nanoparticles enveloping a porous skeleton of sulfonated polyether ether ketone (PEEK) enhance the surface modulus and hardness of sulfonated layer. Ppy‐coated sulfonated PEEK improves phagocytosis and M1 macrophage activation through turning on near‐infrared (NIR) to help clear bacteria; and suppressed phagocytosis and a switch to M2 macrophage occur with closed NIR, which is facilitated to tissue repair.