Formation of pre-metastatic niches induced by tumor extracellular vesicles in lung metastasis. (February 2023)

• Record Type: Journal Article
• Authors: Liu, Yuping; Mao, Dengxuan; Wang, Hong; Che, Xiaoyu; Chen, Yan
• Is Part Of: Pharmacological research. Volume 188(2023)
• Publication Date: 2023-02
• Subjects: ABHD5 a/b-hydrolase domain-containing 5 -- ABs apoptotic bodies -- ANXA6 annexin A6 -- B4GALT3 β-1, 4-Galactosyltransferase III -- BACH2 basic leucine zipper transcription factor 2 -- BAG6 Bcl2-associated anthogene 6 -- BALF bronchoalveolar lavage fluid -- BMDCs bone marrow-derived cells -- CAFs Cancer associated fibroblasts -- CBSA cationic bovine serum albumin -- CCL2 C-C motif chemokine ligand 2 -- CCL5 C-C motif chemokine ligand 5 -- CCR CC, clear cell renal cell carcinoma -- CELSR1 nonclassical cadherin -- CH25H cholesterol 25-hydroxylase -- CHK1 checkpoint kinase 1 -- CLP-MBs cationic lipoplexes containing RNA target-sensing molecular beacons -- COL6A1 collagen type VI alpha 1 -- COX-2 cyclooxygenase 2 -- CRC colorectal cancer -- CTCs Circulating Tumor Cells -- CXCL1 interferon gamma induced protein 1 -- CXCL10 interferon gamma induced protein 10 -- DCs dendritic cells -- DLS dynamic light scattering -- DOX doxorubicin -- DTCs Disseminated tumor cells -- ECM extracellular matrix -- ENVs Exosome-like nanovesicles -- ESCC oesophageal squamous cell carcinoma -- ESCRT endocytic sorting complex required for transport -- EVs extracellular vesicles -- Exos exosomes -- FN fibronectin -- FTIR Fourier transform infrared -- GATA-3 GATA-binding factor 3 -- H2AX H2A histone family member X -- HCC hepatocellular carcinoma -- HIF1α Hypoxia-inducible factor-1 -- HS heparan sulfate -- HSP heat shock proteins -- HUVEC human umbilical vein endothelial cell -- IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 -- IL-1 interleukin-1 -- IL-6 interleukin-6, IL-8, interleukin-8 -- ILVs intraluminal vesicles -- KDM6B lysine (K)-specific demethylase 6B -- KLF2 Krueppel-like factor 2 -- lEVs Large extracellular vesicles -- lnc RNAs long non-coding RNAs -- LOX Recombinant Lysyl Oxidase -- LSCM laser scanning confocal microscopy -- LUAD lung adenocarcinoma -- MDSCs myeloid-derived suppressor cells -- MMP2 matrix metalloproteinase-2 -- MMP9 matrix metalloproteinase-9 -- MPM-FLIM multiphoton microscopy with fluorescence lifetime imaging -- MPs microvesicles -- MSIA mass spectrometric immunoassay -- MSNs mesoporous silica nanoparticles -- MV microvesicle -- MVBs multi-vesicular bodies -- MVEs multivesicular endosomes -- NDPK nucleoside diphosphate kinase -- NFKBID NF-κB inhibitor delta -- NGS next-generation RNA sequencing -- NID1 nidogen 1 -- NK natural killer cell -- NLRP3 NOD-like receptor thermal protein domain associated protein 3 -- NSCLC non-small cell lung carcinoma -- nSMase2 neutral sphingomyelinase 2 -- NTA nanoparticle tracking analysis -- OS osteosarcoma -- PGs proteoglycans -- PKM2 Pyruvate kinase, muscle 2 -- PLD1 phospholipase D1 -- PMN pre-metastatic niche -- PMos patrolling monocytes -- PPIs Proton pump inhibitors -- PRKD1 protein kinase D1 -- RCP Rab coupling protein -- sEVs small extracellular vesicles -- SAA3 serum amyloid A3 -- SACC salivary adenoid cystic carcinoma -- SCLC small cell lung cancer -- SEC-MALLS scattering combined with size exclusion chromatography -- SEM scanning electron microscopy -- SPR surface plasmon resonance -- TAM tumor-associated macrophages -- TF tissue factor -- Tf transferrin -- TGF-β transforming growth factor-β -- TIMP metalloproteinase inhibitor -- TKI tyrosine kinase inhibitors -- TLR3 Toll-like receptor 3 -- TNBC triple-negative breast cancer -- TRIM59 tumor cells-derived exosomal tripartite motif-containing 59 -- ZO-1 Zonula occludens protein 1 -- 25HC 25-hydroxycholesterol; Extracellular vesicle -- Pre-metastatic niche -- Lung metastasis -- Mechanisms -- Strategy; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2023.106669
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: There are a number of malignant tumors that metastasize into the lung as one of their most common sites of dissemination. The successful infiltration of tumor cells into distant organs is the result of the cooperation between tumor cells and distant host cells. When tumor cells have not yet reached distant organs, in situ tumor cells secrete extracellular vesicles (EVs) carrying important biological information. In recent years, scholars have found that tumor cells-derived EVs act as the bridge between orthotopic tumors and secondary metastases by promoting the formation of a pre-metastatic niche (PMN), which plays a key role in awakening dormant circulating tumor cells and promoting tumor cell colonization. This review provides an overview of multiple routes and mechanisms underlying PMN formation induced by EVs and summaries study findings that underline a potential role of EVs in the intervention of lung PMN, both as a target or a carrier for drug design. In this review, the underlying mechanisms of EVs in lung PMN formation are highlighted as well as potential applications to lung metastasis diagnosis and treatment. Graphical Abstract: ga1