Synthesis and characterization of potential impurities of ezetimibe. (1st November 2022)

• Record Type: Journal Article
• Authors: Satheesh, Deekonda; Devi, Dharmasoth Rama; Basavaiah, Keloth; Sreenivasulu, B.; Reddy, Bhavanam Sekhara; Aegurla, Balakrishna; Kumar, Pallerla Satish; Guduri, Anil Kumar; Chavakula, Ramadas
• Is Part Of: Journal of heterocyclic chemistry. Volume 60:Number 2(2023)
• Page Start: 318
• Page End: 326
• Publication Date: 2022-11-01
• Subjects: API -- ezetimibe -- des‐fluoro aniline analog -- ICH -- m‐fluoro aniline analog -- o‐fluorobenzene isomer -- related substances; Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.4584
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract: Ezetimibe is an azetidinone derivative and a substituted β‐lactam, it is a hypolipidemic agent, and a drug substance that lowers the cholesterol levels in our body. The present work describes the origin, synthesis, and characterization of three impurities of ezetimibe, which are also positional isomers and/or related substances of ezetimibe. viz: o ‐Fluoro benzene isomer, m ‐Fluoro aniline analog, and des ‐fluoro aniline analogs of ezetimibe. Abstract : Synthesis and characterization of potential impurities of ezetimibe.