New compounds from the stems of Fissistigma acuminatissimum Merr. and their in vitro anti-inflammatory activity. Issue 4 (16th February 2023)

• Record Type: Journal Article
• Authors: Jin, Chen; Zhang, Ling; Yuan, Cheng-Jun; Liu, Yi; Liu, Hui-Zhen; Xu, Bo-Lun; Shu, Ji-Cheng; Zhang, Xiao-Yu; Wang, Si-Yi; Huang, Hui-Lian
• Is Part Of: Natural product research. Volume 37:Issue 4(2023)
• Page Start: 551
• Page End: 559
• Publication Date: 2023-02-16
• Subjects: Fissistigma acuminatissimum Merr. -- 3-benzoylbenzofuran -- dihydrochalcone -- phenylethyl benzoate -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2022.2076231
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new compounds, 4, 5, 6, 7-tetramethoxy-3-benzoylbenzofuran (1 ), 4-hydroxy-3, 5, 6-trimethoxydihydrochalcone-2-O-β-D-glucopyranoside (2 ) and 2-hydroxy-3, 4, 5, 6-tetramethoxyphenylethyl benzoate (3 ) along with five known flavonoids were isolated from the dichloromethane fraction of the stems of Fissistigma acuminatissimum Merr.'s ethanol extracts. The compounds were obtained by chromatographic methods and the structure elucidation was completed primarily on the basis of spectroscopic analyses, all of these compounds were isolated from F. acuminatissimum for the first time. All the fractions and compounds were evaluated for their anti-inflammatory activity against lipopolysaccharide (LPS)-stimulated tumor necrosis factor α (TNF-α) production in RAW264.7 cells in vitro. The dichloromethane fraction showed the most potent inhibition(38.2%) at 60 μg/mL, compound 1 (70.2%) and 3 (65.2%) showed significant inhibition at 10 μM. Graphical Abstract: UF0001