Engineered Phage with Aggregation‐Induced Emission Photosensitizer in Cocktail Therapy against Sepsis (Adv. Mater. 6/2023). Issue 6 (9th February 2023)

• Record Type: Journal Article
• Authors: Wu, Ming‐Yu; Chen, Luojia; Chen, Qingrong; Hu, Rui; Xu, Xiaoyu; Wang, Yifei; Li, Jie; Feng, Shun; Dong, Changjiang; Zhang, Xiao‐Lian; Li, Zhiqiang; Wang, Lianrong; Chen, Shi; Gu, Meijia
• Is Part Of: Advanced materials. Volume 35:Issue 6(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-09
• Subjects: aggregation‐induced emission -- phage cocktail therapy -- photodynamic therapy -- photosensitizers -- sepsis; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202370041
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Sepsis Therapy In article number 2208578, Ming‐Yu Wu, Luojia Chen, Lianrong Wang, Shi Chen, Meijia Gu, and co‐workers develop a novel strategy combining an AIE photosensitizer with a phage that not only selectively identifies bacterial species but also shows a powerful ability to kill pathogenic bacteria in sepsis diagnosis and treatment. This synergetic therapy strategy combining phage cocktail therapy and photodynamic therapy offers a strong "1 + 1 > 2" bactericidal efficacy in vitro and in vivo.