Economic Electrochemical Sensors for the Determination of Eszopiclone in Pharmaceutical Formulation with Greenness Profile Assessment. Issue 2 (15th June 2022)

• Record Type: Journal Article
• Authors: El‐Yazbi, Amira F.; Sabry, Suzy M.; Moneeb, Marwa S.; Elgammal, Feda A. H.; Essam, Hebatallah M.
• Is Part Of: Electroanalysis. Volume 35:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-15
• Subjects: Eszopiclone -- Ion Selective Electrode -- Tetraphenylborate -- Tetrakis -- Nitrophenyl octyl ether -- Greenness assessment; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202200082
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: Electrochemical‐ion‐selective‐sensors offer green, rapid, economic and simple analytical‐tool in pharmaceutical industry, control processes, physiological measurements and environmental monitoring. In this study, two sensors were introduced for eszopiclone (EZP) determination in pure‐form and in pharmaceutical‐dosage‐forms using drug‐ion‐exchanger association complex fabrication technique. Two different ion‐exchangers were used and compared, tetrakis (4‐chlorophenyl) borate in sensor1 and tetraphenyl borate in sensor 2. Such sensors showed superior performance at pH 3.5 over a wide‐range of EZP concentration. The proposed method was also assessed using GAPI and analytical Eco‐scale. Low cost, short analysis‐time, simplicity and greenness of the proposed sensors allow their use for high‐through‐put analysis in quality‐control laboratories. Abstract :