Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae). Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Katja, Dewa Gede; Hilmayanti, Erina; , Nurlelasari; Mayanti, Tri; Harneti, Desi; Maharani, Rani; Farabi, Kindi; , Darwati; Lesmana, Ronny; Fajriah, Sofa; Supratman, Unang; Azmi, Mohamad Nurul; Shiono, Yoshihito
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 1(2023)
• Page Start: 36
• Page End: 43
• Publication Date: 2023-01-02
• Subjects: Chisocheton lasiocarpus -- limonoid -- lasiocarpine -- cytotoxic activity -- MCF-7 cell line; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2032678
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new azadirone-type limonoids, namely lasiocarpine A (1 ) and lasiocarpine B (2 ) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3 –5 ). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1 ) showed the strongest activity with an IC50 value of 43.38 μM. Graphical Abstract: UF0001