Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae. (2nd September 2022)

• Record Type: Journal Article
• Authors: Swank, Zoe; Senussi, Yasmeen; Manickas-Hill, Zachary; Yu, Xu G; Li, Jonathan Z; Alter, Galit; Walt, David R
• Is Part Of: Clinical infectious diseases. Volume 76:Number 3(2023)
• Page Start: e487
• Page End: e490
• Publication Date: 2022-09-02
• Subjects: COVID-19 -- post-acute sequelae of COVID-19 (PASC) -- long COVID -- SARS-CoV-2 antigens -- spike; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac722
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.