Prevalence, Outcome, and Prevention of Congenital Cytomegalovirus Infection in Neonates Born to Women With Preconception Immunity (CHILd Study). (19th June 2022)

• Record Type: Journal Article
• Authors: Lilleri, Daniele; Tassis, Beatrice; Pugni, Lorenza; Ronchi, Andrea; Pietrasanta, Carlo; Spinillo, Arsenio; Arossa, Alessia; Achille, Cristian; Vergani, Patrizia; Ornaghi, Sara; Riboni, Silvia; Cavoretto, Paolo; Candiani, Massimo; Gaeta, Gerarda; Prefumo, Federico; Fratelli, Nicola; Fichera, Anna; Vignali, Michele; Barbasetti Di Prun, Allegra; Fabbri, Elisa; Cetin, Irene; Locatelli, Anna; Consonni, Sara; Rutolo, Simona; Miotto, Elena; Savasi, Valeria; Di Giminiani, Maria; Cromi, Antonella; Binda, Sandro; Fiorina, Loretta; Furione, Milena; Cassinelli, Gabriela; Klersy, Catherine;
• Is Part Of: Clinical infectious diseases. Volume 76:Number 3(2023)
• Page Start: 513
• Page End: 520
• Publication Date: 2022-06-19
• Subjects: human cytomegalovirus -- congenital infection -- nonprimary infection -- preconception immunity; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac482
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Background: Human cytomegalovirus (HCMV) is the leading infectious cause of congenital disabilities. We designed a prospective study to investigate the rate, outcome, and risk factors of congenital CMV (cCMV) infection in neonates born to immune women, and the potential need and effectiveness of hygiene recommendations in this population. Methods: The study was composed of 2 sequential parts: an epidemiology (part 1) and a prevention (part 2) study. Performance of part 2 depended upon a cCMV rate >0.4%. Women enrolled in part 1 did not receive hygiene recommendations. Newborns were screened by HCMV DNA testing in saliva and cCMV was confirmed by urine testing. Results: Saliva swabs were positive for HCMV DNA in 45/9661 newborns and cCMV was confirmed in 18 cases. The rate of cCMV was .19% (95% confidence interval [CI]: .11–.29%), and 3 out of 18 infants with cCMV had symptoms of CMV at birth. Age, nationality, occupation, and contact with children were similar between mothers of infected and noninfected newborns. Twin pregnancy (odds ratio [OR]: 7.2; 95% CI: 1.7–32.2; P = .037) and maternal medical conditions (OR: 3.9; 95% CI: 1.5–10.1; P = .003) appeared associated with cCMV. Given the rate of cCMV was lower than expected, the prevention part of the study was cancelled. Conclusions: Newborns from women with preconception immunity have a low rate of cCMV, which appears to be mostly due to reactivation of the latent virus. Therefore, serological screening in childbearing age would be pivotal to identify HCMV-seropositive women, whose newborns have a low risk of cCMV. Clinical trials registration: www.clinicaltrials.gov (NCT03973359). Abstract : Congenital HCMV infection occurs in 0.19% of immune mothers, among which it appears mostly due to reactivation of the latent virus. Serological screening in childbearing age is pivotal to identify HCMV-seropositive women, who have a low risk of congenital CMV.