A biodegradable covalent organic framework for synergistic tumor therapy. Issue 6 (18th January 2023)

• Record Type: Journal Article
• Authors: Li, Wen-Yan; Wan, Jing-Jing; Kan, Jing-Lan; Wang, Bo; Song, Tian; Guan, Qun; Zhou, Le-Le; Li, Yan-An; Dong, Yu-Bin
• Is Part Of: Chemical science. Volume 14:Issue 6(2023)
• Page Start: 1453
• Page End: 1460
• Publication Date: 2023-01-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2sc05732h
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : Stimulus-responsive biodegradable nanocarriers with tumor-selective targeted drug delivery are critical for cancer therapy. Abstract : Stimulus-responsive biodegradable nanocarriers with tumor-selective targeted drug delivery are critical for cancer therapy. Herein, we report for the first time a redox-responsive disulfide-linked porphyrin covalent organic framework (COF) that can be nanocrystallized by glutathione (GSH)-triggered biodegradation. After loading 5-fluorouracil (5-Fu), the generated nanoscale COF-based multifunctional nanoagent can be further effectively dissociated by endogenous GSH in tumor cells, releasing 5-Fu efficiently to achieve selective chemotherapy on tumor cells. Together with the GSH depletion-enhanced photodynamic therapy (PDT), an ideal synergistic tumor therapy for MCF-7 breast cancer via ferroptosis is achieved. In this research, the therapeutic efficacy was significantly improved in terms of enhanced combined anti-tumor efficiency and reduced side effects by responding to significant abnormalities such as high concentrations of GSH in the tumor microenvironment (TME).