A metal-free protocol for the preparation of amines using ammonia borane under mild conditions. Issue 4 (12th January 2023)

• Record Type: Journal Article
• Authors: Li, Xinmin; Hu, Yue; Alenad, Asma M.; Zhou, Bei; Ma, Zhuang; Gao, Jie; Jagadeesh, Rajenahally V.; Beller, Matthias
• Is Part Of: Organic chemistry frontiers. Volume 10:Issue 4(2023)
• Page Start: 970
• Page End: 976
• Publication Date: 2023-01-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo01938h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A mild and convenient reductive amination protocol for the synthesis of structurally diverse secondary and tertiary amines as well as N -methylated products under metal-free conditions is presented. Abstract : A mild and convenient reductive amination protocol for the synthesis of structurally diverse secondary and tertiary amines as well as N -methylated products under metal-free conditions is presented. This one-pot protocol works efficiently at room temperature using ammonia borane as the reductant and is applicable to a wide range of substrates, including chiral amines and amino acid derivatives. The synthetic utility and practicability of this methodology is demonstrated by gram-scale reactions and selected synthesis of current drug molecules.