An entropy-driven DNA nanomachine for microRNA detection using a personal glucose meter. Issue 10 (17th January 2023)

• Record Type: Journal Article
• Authors: Wang, Qing; He, Yuqiu; He, Shizhen; Yu, Shanshan; Jiang, Yuqian; Wang, Fuan
• Is Part Of: Chemical communications. Volume 59:Issue 10(2023)
• Page Start: 1345
• Page End: 1348
• Publication Date: 2023-01-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06479k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A reliable and portable TDR-PGM nanomachine was facilely constructed for highly sensitive detection of miRNA by integrating the entropy-driven TDR amplifier and the catalytic invertase biocatalyst. Abstract : Herein, we developed a reliable and portable biosensor (TDR-PGM nanomachine) for the sensitive detection of microRNA by integrating an efficient toehold-mediated strand displacement reaction module (TDR) and a personal glucose meter (PGM). The system provides a versatile methodology for microRNA detection in real samples and holds broad prospects in point-of-care diagnosis.