An NIR fluorescent/photoacoustic dual-mode probe of NADPH for tumor imaging. Issue 12 (20th January 2023)

• Record Type: Journal Article
• Authors: Guan, Liandi; Hu, Wanting; Zuo, Hongzhi; Sun, Hua; Ai, Yongjian; He, Meng-qi; Ma, Cheng; Ding, Mingyu; Liang, Qionglin
• Is Part Of: Chemical communications. Volume 59:Issue 12(2023)
• Page Start: 1617
• Page End: 1620
• Publication Date: 2023-01-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06354a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : In this work, we synthesized a novel turn-on probe to monitor NADPH levels in energy metabolism and medication of cancer cells and tumor-bearing mice by NIR fluorescent/photoacoustic bimodal imaging with high sensitivity and selectivity. Abstract : A novel probe was synthesized with a turn-on NIR fluorescent (NIRF)/photoacoustic (PA) response to NADPH, which was successfully applied in both monitoring intracellular NADPH and dual-modal imaging of tumor-bearing mice. It exhibits good potential in studying and understanding the tumor energy metabolism and treatment process related to NADPH.