Novel receptors for bacterial protein toxins. (February 2015)

• Record Type: Journal Article
• Authors: Schmidt, Gudula; Papatheodorou, Panagiotis; Aktories, Klaus
• Is Part Of: Current opinion in microbiology. Volume 23(2015)
• Page Start: 55
• Page End: 61
• Publication Date: 2015-02
• Subjects: Microbiology -- Periodicals; 579.05
• DOI: 10.1016/j.mib.2014.11.003
• Languages: English
• ISSNs: 1369-5274

Abstract

Highlights: Host cell receptor identification is crucial for understanding toxins. Several novel toxin receptors have been identified by optimized protocols. Novel toxin receptors identified are ADAM10 for S. aureus α-toxin, Lu/BCAM for E. coli CNF1, LSR for C. difficile transferase CDT and LRP1 for C. perfringens TpeL toxin. Abstract : While bacterial effectors are often directly introduced into eukaryotic target cells by various types of injection machines, toxins enter the cytosol of host cells from endosomal compartments or after retrograde transport via Golgi from the ER. A first crucial step of toxin–host interaction is receptor binding. Using optimized protocols and new methods novel toxin receptors have been identified, including metalloprotease ADAM 10 for Staphylococcus aureus α-toxin, laminin receptor Lu/BCAM for Escherichia coli cytotoxic necrotizing factor CNF1, lipolysis stimulated lipoprotein receptor (LSR) for Clostridium difficile transferase CDT and low-density lipoprotein receptor-related protein (LRP) 1 for Clostridium perfringens TpeL toxin.