Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy. (16th March 2023)

• Record Type: Journal Article
• Authors: Zhang, Yulu; Long, Yu; Wan, Jinyan; Liu, Songyu; Shi, Ai; Li, Dan; Yu, Shuang; Li, Xiaoqiu; Wen, Jing; Deng, Jie; Ma, Yin; Li, Nan
• Is Part Of: Journal of drug targeting. Volume 31:Number 3(2023)
• Page Start: 229
• Page End: 242
• Publication Date: 2023-03-16
• Subjects: Macrophage -- macrophage membrane -- biomimetic drug delivery systems -- inflammation targeting -- inflammation-related diseases; Drug delivery systems -- Periodicals; Drug Delivery Systems; Vehicles; Drug Administration Routes; Drug Evaluation; 615.7
• DOI: 10.1080/1061186X.2022.2071426
• Languages: English
• ISSNs: 1061-186X

Abstract

Abstract: In recent years, there have been many exciting developments in the biomedical applications of the macrophage membrane bionic drug delivery system (MM-Bio-DDS). Macrophages, as an important immune cell, are involved in initiating and regulating the specific immune response of the body. Therefore, the inflammatory process related to macrophages is an important goal in the diagnosis and treatment of many diseases. In this review, we first summarise the different methods of preparation, characterisation, release profiles and natural advantages of using macrophages as a drug delivery system (DDS). Second, we introduce the processes of various chronic inflammatory diseases and the role of macrophages in them, specifically clarifying how the MM-Bio-DDS provides a wide and effective treatment for the targeted inflammatory site. Finally, based on the existing research, we propose the application prospect and existing challenges of the MM-Bio-DDS, especially the problems in clinical transformation, to provide new ideas for the development and utilisation of the MM-Bio-DDS in targeted drug delivery for inflammation and the treatment of diseases.