Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models. (17th February 2023)

• Record Type: Journal Article
• Authors: Bessa, Maria João; Brandão, Fátima; Rosário, Fernanda; Moreira, Luciana; Reis, Ana Teresa; Valdiglesias, Vanessa; Laffon, Blanca; Fraga, Sónia; Teixeira, João Paulo
• Is Part Of: Journal of toxicology and environmental health. Volume 26:Number 2(2023)
• Page Start: 67
• Page End: 96
• Publication Date: 2023-02-17
• Subjects: Nanoparticles -- respiratory models -- in vitro -- submerged cultures -- air-liquid interface -- toxicity testing; Toxicology -- Periodicals; Environmental toxicology -- Periodicals; Environmental health -- Periodicals; 615.90205
• DOI: 10.1080/10937404.2023.2166638
• Languages: English
• ISSNs: 1093-7404

Abstract

ABSTRACT: Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an overview of the available human respiratory models and exposure systems for in vitro testing, advantages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.