Phenylpropanoids from Solanum capsicoides and their anti-inflammatory activity. Issue 2 (1st February 2023)

• Record Type: Journal Article
• Authors: Wang, Han; Liu, Yan; Jang, Yi-Kai; Wang, Si-Yi; Li, Xiao-Mao; Pan, Juan; Guan, Wei; Algradi, Adnan Mohammed; Kuang, Hai-Xue; Yang, Bing-You
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 2(2023)
• Page Start: 118
• Page End: 124
• Publication Date: 2023-02-01
• Subjects: Solanaceae -- phenylpropanoids; Solanum capsicoides -- spectroscopic methods -- anti-inflammatory; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2066529
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new phenylpropanoids, 4-O-(1''-O-cis-caffeoyl)- β -glucopyran osyl-1-allyl-3-methoxy-benzene (1 ), 4'-O-(1''-O-cis-caffeoyl)- β -glucopyranosyl-hydroxymegastigm-4-en-3-one (2 ), together with nine known compounds were obtained from the leaves of Solanum capsicoides . Their structures were elucidated based on spectroscopic methods, and comparing spectral data with those in literature. Meanwhile, their anti-inflammatory activities were evaluated on (LPS)-induced RAW 246.7 cells, and 1, 9, and 10 showed better inhibitory effects with IC50 values of 17.19 ± 1.12, 18.15 ± 0.47, and 19.8 ± 0.95 μM, respectively. Graphical Abstract: UF0001