Two new isoflavones from the roots of Sophora tonkinensis. Issue 2 (1st February 2023)

• Record Type: Journal Article
• Authors: Chen, Dao-Jun; Yuan, Shuang; Zhang, Peng; An, Qiao; Zou, Ji-Bin; Yuan, Chun-Mao; Zhao, Li-Hua; Hu, Zhan-Xing; Hao, Xiao-Jiang
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 2(2023)
• Page Start: 163
• Page End: 170
• Publication Date: 2023-02-01
• Subjects: Fabaceae -- Sophora tonkinensis -- isoflavone -- anti-TMV -- α-glucosidase inhibitory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2077200
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new isoflavones (1 and 2 ), as well as eight known ones were isolated from the roots of Sophora tonkinensis Gagnep. Compound 1 represents an unprecedented polymerization pattern constructed by isoflavone and cytisine. Their structures were elucidated by comprehensive spectroscopic data analysis, combined with ECD calculations. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity compared with the positive control ningnanmycin. Moreover, compound 6 exhibited potent α -glucosidase inhibitory activity with IC50 value of 47.4 mg/L. Graphical Abstract: UF0001