Microbubbles for human diagnosis and therapy. (March 2023)

• Record Type: Journal Article
• Authors: Fournier, Louise; de La Taille, Thibault; Chauvierre, Cédric
• Is Part Of: Biomaterials. Volume 294(2023)
• Publication Date: 2023-03
• Subjects: Microbubbles -- Ultrasound -- Molecular imaging -- Targeted therapy -- Sonothrombolysis -- Sonoporation; AFM Atomic Force Microscopy -- ARF Acoustic Radiation Force -- BBB Blood Brain Barrier -- BT Brachytherapy -- CNS Central Nervous System -- CO Carbon Monoxide -- CORM Carbon Monoxide Releasing Molecule -- DBCO Dibenzocyclooctyne-amine -- DSPC (1, 2-distearoyl-sn-glycero-3-phosphocholine) -- DSPE-PEG2000 (1 2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [amino (polyethylene glycol)-2000]) -- EDC / NHS 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide -- N-Hydroxy succinimide EPR -- Enhanced Permeability and Retention FDA -- Food and Drug Administration FSHR -- Follicle Stimulating Hormone Receptor FUS -- Focused Ultrasound fUSI -- Functional Ultrasound Imaging HA -- Hyaluronic Acid HGN -- Hallow Gold Nanoshell HIFU -- High Intensity Focused Ultrasound GV -- Gas Vesicle HSA -- Human Serum Albumin JAM-A -- Junctional Adhesion Molecule A KDR -- Kinase Insert Domain LPS -- Lipopolysaccharide MB -- Microbubble MI -- Mechanical Index NB -- Nanobubble NCL -- Nucleolin ND -- Nanodroplet NIR -- Near Infrared NO -- Nitric Oxide NP -- Nanoparticle NPMB -- Nanoparticles assembled as Microbubble PALM -- Photoactivated Localization Microscopy PBS -- Phosphate Buffer Saline PCCA -- Phase Change Contrast Agent PEG -- Polyethylene Glycol PFC -- Perfluorocarbon PFD -- Perfluorodecalin PFOB -- Perfluoro-octyl-Bromide PFOC -- Perfluorocarbon-based Oxygen Carrier PSF -- Point Spread Function RES -- Reticuloendothelial System RF -- Resonance Frequency ROS -- Reactive Oxygen Species SH -- Subharmonic sLex: Sialyl Lewis X peptide -- SPAAC Strain Promoted Alkyne-Azide Cycloaddition -- STAT3 Signal Transducer and Activation of Transcription 3 -- STORM Stochastic Optical Reconstruction Microscopy -- TCCS Transcranial Color Doppler Ultrasound -- Thyc1 Thymocyte Antigen 1 -- US Ultrasound -- ULM Ultrasound Localized Microscopy -- VCAM1 Vascular Cell Adhesion Molecule 1 -- VEGFR2 Vascular Endothelial Growth Factor Receptor 2; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2023.122025
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Microbubbles (MBs) were observed for the first time in vivo as a curious consequence of quick saline injection during ultrasound (US) imaging of the aortic root, more than 50 years ago. From this serendipitous event, MBs are now widely used as contrast enhancers for US imaging. Their intrinsic properties described in this review, allow a multitude of designs, from shell to gas composition but also from grafting targeting agents to drug payload encapsulation. Indeed, the versatile MBs are deeply studied for their dual potential in imaging and therapy. As presented in this paper, new generations of MBs now opens perspectives for targeted molecular imaging along with the development of new US imaging systems. This review also presents an overview of the different therapeutic strategies with US and MBs for cancer, cardiovascular diseases, and inflammation. The overall aim is to overlap those fields in order to find similarities in the MBs application for treatment enhancement associated with US. To conclude, this review explores the new scales of MBs technologies with nanobubbles development, and along concurrent advances in the US imaging field. This review ends by discussing perspectives for the booming future uses of MBs.