Five new compounds from Zingiberis Rhizoma Recens and their anti-apoptotic activity. Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Zhang, Xiao-Juan; Song, Zhi-Min; Yuan, Pei-Pei; Wang, Yan-Zhi; Li, Man-Qian; Liu, Yu-Fei; Hu, Xue-Yu; Feng, Wei-Sheng
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 1(2023)
• Page Start: 1
• Page End: 10
• Publication Date: 2023-01-02
• Subjects: Zingiberis Rhizoma Recens -- gingerol A (1) -- gingerol B (2) -- diphenylheptane glycoside A (3) -- diphenylheptane glycoside B (4) -- anti-apoptotic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2026335
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Five new compounds, named gingerol A (1a and 1b ), gingerol B (2 ), diphenylheptane glycoside A (3 ) and diphenylheptane glycoside B (4 ), were isolated from the acetone extract of Zingiberis Rhizoma Recens. The structures of new compounds were elucidated on the basis of spectroscopic methods including UV, IR, 1D NMR, 2D NMR and HR-ESI-MS. Compounds 2 –4 could significantly decrease the apoptosis rate and increase the survival rate of human normal lung epithelial cells (BEAS-2B) at the concentration of 10 μM. Graphical Abstract: UF0001