Antifouling activity of terpenoids from the corals Sinularia flexibilis and Muricella sp. against the bryozoan Bugula neritina. Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Wu, Zhi-Wen; Wang, Zhi-Xuan; Guo, Yuan-Qiang; Tang, Sheng-An; Feng, Dan-Qing
• Is Part Of: Journal of Asian natural products research. Volume 25:Issue 1(2023)
• Page Start: 85
• Page End: 94
• Publication Date: 2023-01-02
• Subjects: Antifouling terpenoids -- Sinularia flexibilis -- Muricella sp. -- Bugula neritina -- structure-activity relationship (SAR); Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2022.2046562
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Marine natural products are promising sources of green antifoulants. Here, a new compound (1 ) was isolated from the soft coral Sinularia flexibilis . This compound, another nine cembranoids (2 –10 ) from S. flexibilis, and three eunicellin-type diterpenoids (11 –13 ) from the gorgonian Muricella sp. were tested for antifouling activity against larval settlement of the bryozoan Bugula neritina . Compounds 2, 3, 4, 9, 12, and 13 exhibited significant antifouling activity, with EC50 values of 18.2, 99.7, 67.9, 35.6, 33.9, and 49.3 μM, respectively. Analysis of the structure-activity relationships suggested that the hydroxy group at C-13 in compound 4 reduced its antifouling activity. Graphical Abstract: UF0001