A phototoxic thulium complex exhibiting intracellular ROS production upon 630 nm excitation in cancer cells. Issue 14 (19th January 2023)

• Record Type: Journal Article
• Authors: Obitz, Daniel; Gkika, Karmel S.; Heller, Marvin; Keyes, Tia E.; Metzler-Nolte, Nils
• Is Part Of: Chemical communications. Volume 59:Issue 14(2023)
• Page Start: 1943
• Page End: 1946
• Publication Date: 2023-01-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06209g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A thulium(iii ) terypyridine complex was synthesized with a pendant light harvesting antenna. The complex shows significant promise as a photosensitiser (PS) for photodynamic therapy (PDT) upon excitation in the therapeutic window (> 590 nm). Abstract : A lanthanide(iii ) complex with a thulium metal centre connected via a terpyridine unit to a light harvesting antenna with strong absorption in the therapeutic window [>590 nm] was synthesised and tested as a possible photosensitiser (PS) in photodynamic therapy (PDT). The complex exhibited significant phototoxic activity on cancer cells upon irradiation in the therapeutic window and from intracellular and solution studies ROS production was identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold lowered IC50 value was obtained upon irradiation compared to the dark control.