Performance of a Molecular Test for Group A Streptococcus Pharyngitis. Issue 1 (2nd November 2022)

• Record Type: Journal Article
• Authors: Tanz, Robert R; Heaberlin, Lauren E; Harvey, Erin; Katsogridakis, Yiannis L; Burns, Rebecca Ruhana; Rippe, Jason; Shulman, Stanford T
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 12:Issue 1(2023)
• Page Start: 56
• Page End: 59
• Publication Date: 2022-11-02
• Subjects: diagnostic stewardship -- Group A streptococcus -- molecular test -- nucleic acid amplification test -- pharyngitis; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piac115
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: We performed a prospective study to determine if the pretest probability of a positive loop-mediated isothermal amplification test is greater when there are more signs and symptoms of GAS pharyngitis. Patients were enrolled if a clinician obtained a GAS RADT. The McIsaac score was calculated. The prevalence of positive LAMP and RADT results increased as the McIsaac score increased. The calculated sensitivity of LAMP was superior to RADT. Abstract : A highly sensitive NAAT for group A streptococcus (GAS) is more likely to be positive in patients with a greater pretest probability of GAS pharyngitis. The NAAT was much more sensitive than RADT. Clinicians should practice diagnostic stewardship with molecular tests.