Oncological Safety and Potential Cost Savings of Routine vs Selective Histopathological Examination After Appendectomy: Results of the Multicenter, Prospective, Cross-Sectional FANCY Study. Issue 3 (5th March 2023)

• Record Type: Journal Article
• Authors: Bastiaenen, Vivian P.; de Jonge, Joske; Corten, Bartholomeus J.G.A.; de Savornin Lohman, Elise A.J.; Kraima, Anne C.; Swank, Hilko A.; van Vliet, Jaap L.P.; van Acker, Gijs J.D.; van Geloven, Anna A.W.; in 't Hof, Klaas H.; Koens, Lianne; de Reuver, Philip R.; van Rossem, Charles C.; Slooter, Gerrit D.; Tanis, Pieter J.; Terpstra, Valeska; Dijkgraaf, Marcel G.W.; Bemelman, Willem A.
• Other Names: All collaborators of the Dutch Snapshot Research Group author non-byline.; Amelung F.J. author non-byline.; Atema J.J. author non-byline.; Bessems S. author non-byline.; Beunders A.A.M. author non-byline.; Bodewes T.C.F. author non-byline.; den Boer F.C. author non-byline.; Boerma D. author non-byline.; Boerma E.G. author non-byline.; van den Boezem P. author non-byline.; Bökkerink W.J.V. author non-byline.; van den Boogaart D. author non-byline.; Boogerd L.S.F. author non-byline.; Bouwman H. author non-byline.; Broos A. author non-byline.; Brueren L.O. author non-byline.; Bruinsma W.E. author non-byline.; Bruns E.R.C. author non-byline.; Castelijns P.S.S. author non-byline.; de Castro S.M.M. author non-byline.; Consten E.C.J. author non-byline.; Crolla R.M.P.H. author non-byline.; Dam M.J. author non-byline.; Dang Q. author non-byline.; Dekker J.W.T. author non-byline.; Deroose J.P. author non-byline.; Devriendt S. author non-byline.; Dijkema E.J. author non-byline.; Dijkstra N. author non-byline.; Driessen M.L.S. author non-byline.; van Duijvendijk P. author non-byline.; Duinhouwer L.E. author non-byline.; van Duyn E.B. author non-byline.; El-Massoudi Y. author non-byline.; Elfrink A.K.E. author non-byline.; Elschot J.H. author non-byline.; van Essen J.A. author non-byline.; Ferenschild F.T.J. author non-byline.; Gans S.L. author non-byline.; Gaznay C. author non-byline.; Geraedts A.C.M. author non-byline.; van Gessel B.S.H. author non-byline.; Giesen L.J.X. author non-byline.; van Gils N. author non-byline.; Gorgec B. author non-byline.; Gorter R.R. author non-byline.; Govaert K.M. author non-byline.; Greuter G.N. author non-byline.; van Grevenstein W.M.U. author non-byline.; Groot L. author non-byline.; Hardy J.C.A. author non-byline.; Heemskerk J. author non-byline.; Heeren J.F. author non-byline.; Heidotting J. author non-byline.; Heikens J.T. author non-byline.; Hosseinzoi E. author non-byline.; van Iersel J.J. author non-byline.; Inberg B. author non-byline.; Jansen L.J. author non-byline.; Jens A.J.T. author non-byline.; Jilesen A.P.J. author non-byline.; Joosten M. author non-byline.; de Jong L. author non-byline.; Keijzers M. author non-byline.; Klicks R.J. author non-byline.; Kloppenberg F.W.H. author non-byline.; Koedam T.W.A. author non-byline.; Koëter T. author non-byline.; Konsten J.L.M. author non-byline.; Koolen L.J.E.R. author non-byline.; Kruyt Ph. M. author non-byline.; Lange J.F.M. author non-byline.; Lavrijssen B.D.A. author non-byline.; de Leede E.M. author non-byline.; Leliefeld P.H.C. author non-byline.; Linnemann R.J.A. author non-byline.; Lo G.C. author non-byline.; van de Loo M. author non-byline.; Lubbert P.H.W. author non-byline.; Holzik M.F. Lutke author non-byline.; Manusama E. author non-byline.; Masselink I. author non-byline.; Matthée E.P.C. author non-byline.; Matthijsen R.A. author non-byline.; Mearadji A. author non-byline.; Melenhorst J. author non-byline.; Merkus J.W.S. author non-byline.; Michiels T.D. author non-byline.; Moes D.E. author non-byline.; Moossdorff M. author non-byline.; Mulder E. author non-byline.; Nallayici E.G. author non-byline.; Neijenhuis P.A. author non-byline.; Nielsen K. author non-byline.; Nieuwenhuijzen G.A.P. author non-byline.; Nijhuis J. author non-byline.; Okkema S. author non-byline.; Olthof P.B. author non-byline.; van Onkelen R.S. author non-byline.; van Oostendorp S.E. author non-byline.; Plaisier P.W. author non-byline.; Polle S.W. author non-byline.; Reiber B.M.M. author non-byline.; Reichert F.C.M. author non-byline.; van Rest K.L.C. author non-byline.; van Rijn R. author non-byline.; Roozendaal N.C. author non-byline.; de Ruijter W.M.J. author non-byline.; Schat E. author non-byline.; Scheerhoorn J. author non-byline.; Scheijmans J.C.G. author non-byline.; Schimmer J. author non-byline.; Schipper R.J. author non-byline.; Schouten R. author non-byline.; Schreurs W.H. author non-byline.; Schrijver W.A.M.E. author non-byline.; Shapiro J. author non-byline.; Siemons A. author non-byline.; Silvis R. author non-byline.; Simkens G.A. author non-byline.; Smakman N. author non-byline.; Smeets B.J.J. author non-byline.; Sonneveld D.J.A. author non-byline.; van Suijlichem M. author non-byline.; Talsma A.K. author non-byline.; Thoolen J.M.M. author non-byline.; van Tol R.R. author non-byline.; Tournoij E. author non-byline.; Tseng L.N.L. author non-byline.; Tuynman J.B. author non-byline.; van der Velde K. author non-byline.; Veltkamp S.C. author non-byline.; Verbeek F.P.R. author non-byline.; Verdaasdonk E. author non-byline.; Verhaak T. author non-byline.; Verheuvel N.C. author non-byline.; Vermaas M. author non-byline.; Verseveld M. author non-byline.; Vlek S. author non-byline.; Vogels S. author non-byline.; van de Voort E.M.F. author non-byline.; van Vugt S.T. author non-byline.; Wegdam J.A. author non-byline.; Wennekers M.M. author non-byline.; Wiering B. author non-byline.; de Wijkerslooth E.M.L. author non-byline.; Wijkmans A.A. author non-byline.; Wijnhoven B.P.L. author non-byline.; Witjes C.D.M. author non-byline.; Wolfhagen N. author non-byline.; de Zeeuw S. author non-byline.; van Zoonen G. author non-byline.;
• Is Part Of: Annals of surgery. Volume 277:Issue 3(2023)
• Page Start: e578
• Page End: e584
• Publication Date: 2023-03-05
• Subjects: appendectomy -- appendicitis -- histopathology -- pathology -- routine -- selective; Surgery -- Periodicals; 617.005
• DOI: 10.1097/SLA.0000000000005228
• Languages: English
• ISSNs: 0003-4932

Abstract

Abstract : Objective: To investigate the oncological safety and potential cost savings of selective histopathological examination after appendectomy. Background: The necessity of routine histopathological examination after appendectomy has been questioned, but prospective studies investigating the safety of a selective policy are lacking. Methods: In this multicenter, prospective, cross-sectional study, inspection and palpation of the (meso)appendix was performed by the surgeon in patients with suspected appendicitis. The surgeon's opinion on additional value of histopathological examination was reported before sending all specimens to the pathologist. Main outcomes were the number of hypothetically missed appendiceal neoplasms with clinical consequences benefiting the patient (upper limit two-sided 95% confidence interval below 3:1000 considered oncologically safe) and potential cost savings after selective histopathological examination. Results: Seven thousand three hundred thirty-nine patients were included. After a selective policy, 4966/7339 (67.7%) specimens would have been refrained from histopathological examination. Appendiceal neoplasms with clinical consequences would have been missed in 22/4966 patients. In 5/22, residual disease was completely resected during additional surgery. Hence, an appendiceal neoplasm with clinical consequences benefiting the patient would have been missed in 1.01:1000 patients (upper limit 95% confidence interval 1.61:1000). In contrast, twice as many patients (10/22) would not have been exposed to potential harm due to re-resections without clear benefit, whereas consequences were neither beneficial nor harmful in the remaining seven. Estimated cost savings established by replacing routine for selective histopathological examination were €725, 400 per 10, 000 patients. Conclusions: Selective histopathological examination after appendectomy for suspected appendicitis is oncologically safe and will likely result in a reduction of pathologists' workload, less costs, and fewer re-resections without clear benefit.